For this reason the use of animal models is often an essential step in the testing of orthopaedic and dental implants prior to clinical use in humans. The rabbit as an animal model for experimental surgery. Our endeavor in this article is to integrate all the data about maintaining rabbits as a model and to critically analyze Since no single experimental model provides the complete picture of OA in humans, a variety of animals have served to advance OA research including mouse, rat, guinea pig, rabbit, dog, and horse. 184-204. Rabbits are one of the most used experimental animals for biomedical research, particularly as a widely-used bioreactor for the production of antibodies. This model is being used to evaluate the efficacy of anti-orthopox treatments such as cidofovir and ST-246 which inhibit assembly of the viral envelope and escape of the virus from RPV-infected cells ( Smee, 2008 ) and novel vaccines ( Garza et al., 2009 ). Thomas, Betsy Sara and Bhat, KM ABSTRACT. They have gained favour for their numerous advantages even though they should be ideally used prior to testing in a larger animal model. Developing alternative methods is essential. World Rabbit Sci 14, 1-14. Although the macrostructure and microstructure of rabbit bone are dissimilar to human bone, rabbits are commonly used for screening implant material prior to testing in a larger animal model. Amongst various strains, New Zealand white strains of rabbits are commonly being used for research activities. The rabbit as experimental model for research in implant dentistry and related tissue regeneration. Given the body measures and anatomy, the rabbit is a good subject of bone and tooth researches and experimental surgery. ISSN 1652-8697 . Author links open overlay panel … Comp… Author information: (1)Cell Therapy Center, University Hospital Antonio Pedro, Fluminense Federal University, Niteroi, RJ, Brazil. “The Rabbit as an Experimental, Model Animal”. The ability of the rabbit to develop diseases once sensitised with several stimuli at birth provides opportunities to investigate the risk factors that contribu… The objective of this work is to analyze the laryngofissure with vocal cords grafts as an experimental surgical technique in male adult rabbits in order to contribute with data for the future development of other research projects. Dental Research Journal, 9 (1). The social perception of the animal's "worthiness" is called “speciesism”. The social perception of the animal's "worthiness" is called “speciesism”. Rabbits appear as a first-hand choice for fundamental implant design studies because of … Sveriges lantbruksuniversitet . Since no single experimental model provides the complete picture of OA in humans, a variety of animals have served to advance OA research including mouse, rat, guinea pig, rabbit… 111-118. The critique is based on some anatomical differences, properties of the vitreous humor, and observed differences in drug concentrations in the anterior chamber after intravitreal injections. Volume 137, August 2015, Pages 111-124. Review. Animal models have been used in experimental research to increase human knowledge and contribute to finding solutions to biological and biomedical questions. Smaller animal models that can be easily housed make experimental conditions easier to control and can be used in quantities necessary to sufficiently power research studies. In Vivo Evaluation of The Novel Nanocomposite Porous 3D Scaffold in a Rabbit Model (1).pdf, In Vivo Evaluation of The Novel Nanocomposite Porous 3D Scaffold in a Rabbit Model.pdf, Assessment of bovine biomaterials containing bone morphogenetic proteins bound to absorbable hydroxyapatite in rabbit segmental bone defects 1 Avaliação de biomateriais bovinos contendo proteínas morfogenéticas ósseas absorvidas a hidroxiapatita em defeitos ósseos segmentares em coelhos, The role of biological adhesive and suture material on rabbit hepatic injury. Though experimentation on rabbits seems to be easy there are many pitfalls. Rabbits are one of the most used experimental animals for biomedical research, particularly as a bioreactor for the production of antibodies. 1.) monicacalasans@terra.com.br They have gained favour for their numerous advantages even though they should be ideally used prior to testing in a larger animal model. Sorry, preview is currently unavailable. Application of rabbits in biomedical research: a review. Animal models in eye research, Tsonis P.A., ed. 22. (2008). The aim of this review consists in outlining the use of the rabbit for research in implant dentistry and related tissue regeneration. 5, pp. Fakulteten för veterinärmedicin och husdjursvetenskap . (2012) Experimental animal models of hypertension and atherosclerosis have become a valuable tool for providing information on etiology, pathophysiology, and complications of the disease and on the efficacy and mechanism of action of various drugs and compounds used in treatment. The Rabbit as an Experimental, Model Animal Citation: Sandor Gy Fekete. At this point in time, animal research cannot be entirely replaced by in vitro testing. Calasans-Maia MD(1), Monteiro ML, Ascoli FO, Granjeiro JM. The rabbit is the only small animal model for human smallpox in which natural aerosol transmission has been reported (Adams et al., 2007). Alternatively, use our A–Z index Cite . BibTex; Full citation; Publisher: 'Medknow' Year: 2012. Overall, the rabbit is a useful model for studying lung physiology and pathophysiology. In biomedical research, animal models are primarily used in experiments to learn about the anatomy, genetics and physiology of humans without putting human life at risk. Although the macrostructure and microstructure of rabbit bone are dissimilar to human bone, rabbits are commonly used for screening implant material prior to testing in a larger animal model. The rabbit as a model offers better understanding of lung structure than smaller animal models. Animal model, experimental model, rabbit model. The use of rabbits for experimental research has a long historical tradition. model. This is more so in place where the veterinary facilities are not easily available.Span Rabbits are commonly used as subjects for screening implant material. it on the basis of our experimentation. By BetsySara Thomas, KM Bhat and Manjeet Mapara. The rabbit (Oryctolagus cuniculus) is an important animal species widely used for biomedical research purposes, meat production and as a pet animal. You can download the paper by clicking the button above. Amongst various strains, New Zealand white strains of rabbits are commonly being used for research activities. However, increased concern for the welfare of the animals used, and a growing awareness of the concept of animal rights, has brought a greater focus on the related ethical issues. To complete the lacking medical literature, we herein provide such data for the rabbit model. 266-282. There are numerous biomedical and scientific applications that include important areas such as antibody … Experimental eye research. Dentistry > MCODS Manipal > Periodontology, http://eprints.manipal.edu/id/eprint/79812. Gwon A (2008). 22. Examensarbete 2013:14 . [9,10] A broad range of rabbit OA models have been used extensively and continue to offer specific advantages over other models for OA research. EC Veterinary Science 4.4 (2019): 257-258. Developing alternative methods is essential. Although their numbers have declined over the past two decades, 205,482 rabbits were held in laboratories in 2012. The rabbit is used also as a model for Alzheimer disease. Both accurate description of its normal development and comparative staging with human development will be mandatory. The experimental manipulation can take many forms, including exposure to biological agents such as an infectious virus or bacteria, exposure to chemical agents such as a carcinogen, or even surgical manipulations to cause a condition. Stübinger S(1), Dard M. Author information: (1)Musculoskeletal Research Unit, University of Zurich , Zurich , Switzerland. Del Amo Eva M, Urtti Arto. Eye Research and Ocular Cancer Key advantages to using rabbits as experimental models for ophthalmic research are the size of the rabbit eye, a large body of accumulated data on the anatomy and physiology of the rabbit eye, and most importantly its similarity to the human eye (Gwon 2008). Experimental Eye Research. Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data. Discover our research outputs and cite our work. Key Words: Animal model, experimental model, rabbit model They are also frequently … The use of rabbits for experimental research has a long historical tradition. Using animals like monkeys, dogs or cats as models will likely evoke adverse reactions nowadays. However, information on precautions when using this animal as an experimental model is limited. The white New Zealand rabbit (Oryctolagus cuniculus) is frequently used as a model for in vivo studies. Dental Research Journal (2012-01-01) Rabbit as an animal model for experimental research Manjeet Mapara, Betsy Sara Thomas, K M Bhat; Affiliations Researchers involved in the field of congenital malformations are often forced to work on an animal model. By BetsySara Thomas, KM Bhat and Manjeet Mapara. To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser. BibTex; Full citation; Publisher: 'Medknow' Year: 2012. Cyril and Methodius, Faculty of Natural Sciences Trnava, Slovak Republic ABSTRACT Use of the rabbit as a model and farm animals builds on the rich … The same is true for research. Rabbit model. Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data. Discover our research outputs and cite our work. Enter the email address you signed up with and we'll email you a reset link. The animals models normally used for studies relating to operative techniques are pigs (3), dogs (4-8), rabbits (9) and cats (10). Examensarbete inom veterinärprogrammet . (2013). (Amsterdam, Netherlands, Elsevier), pp. Cite . Animal models for atherosclerosis, restenosis, and endovascular aneurysm repair. Rabbit as an animal model for experimental research Animal experimentation is carried out in consultation with the veterinary wing but it is essential that be familiar with experimental protocols of animal model to be able to design an approriate study. An animal model has been developed to study hypertension and atherosclerosis for several reasons. 2015. The rabbit as an animal model in dental implant research – with special reference to bone augmenting materials . The white New Zealand rabbit (Oryctolagus cuniculus) is frequently used as a model for in vivo studies.However, information on precautions when using this animal as an experimental model is limited. Experimental animal models are models wherein a disease or condition is induced in animals by the scientist. DOI identifier: 10.4103/1735-3327.92960. This is more so in place where the veterinary facilities are not easily available.Span Rabbits are commonly used as subjects for screening implant material. Though experimentation on rabbits seems to be easy there are many pitfalls. Rabbits are one of the most commonly used animals in research and testing, second only to guinea pigs. Kónya A et al. In addition, many unique features of the rabbit have also made it an excellent species for investigating a number of … Rabbit as an animal model for experimental research . Search type Research Explorer Website Staff directory. The white New Zealand rabbit (Oryctolagus cuniculus) is frequently used as a model for in vivo studies. This review discusses some of the more commonly available and frequently used animal models such as the dog, sheep, goat, pig and rabbit models for the evaluation of bone-implant interactions. The same is true for research. The rabbit in cataract/IOL surgery. 26, No. At this point in time, animal research cannot be entirely replaced by in vitro testing. Institutionen för Kliniska Vetenskaper . DOI identifier: 10.4103/1735-3327.92960. Rabbits are often used as models in research, because these animals have several morphological similarities in the hepatic vascular system to humans [].Moreover, the rabbit VX2 tumour model is commonly adopted in experimental oncology because it allows the preclinical evaluation of several embolic agents and endovascular devices [].Any experimental development on surgical or … Animal experimentation is carried out in consultation with the veterinary wing but it is essential that be familiar with experimental protocols of animal model to be able to design an approriate study. The Rabbit as Experimental Model for Research in Implant Dentistry and Related Tissue Regeneration. Journal of Investigative Surgery: Vol. Laboratory rabbits can be purchased from commercial vendors such as Covance, and range from $89-$292 per animal, depending on age and weight. By Eva M. del Amo, Arto Urtti, Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data, Experimental Eye Research, Available online 12 May 2015 research in humans as well as experimental animal models will be important for the discovery of new therapeutics. The rabbit model provides a more suitable small animal model for the assessment of cartilage repair as they have larger joints and are a good size for easy surgical procedures and specimen handling with a cartilage thickness of 0.25 mm–0.75 mm (Table 1) (Fig. Our endeavor in this article is to integrate all the data about maintaining rabbits as a model and to critically analyze it on the basis of our experimentation. This review of the literature covers the gamut Some of the fields for which the rabbit often serves as a primary experimental model include atherosclerosis, Alzheimer’s disease, eye research, osteoarthritis, and tuberculosis. However, many unique features of the rabbit have also made it as an excellent species for examining a number of aspects of human diseases such as atherosclerosis. (ASTM F2451–05 2010). New Zealand White rabbits, large albino rabbits, are the most common breeds of rabbits used in research, although other breeds, including Dutch Belted rabbits are used as well. Hypertension and atherosclerosis are among the most common causes of mortality in both developed and developing countries. By Eva M. del Amo, Arto Urtti, Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data, Experimental Eye Research… Using animals like monkeys, dogs or cats as models will likely evoke adverse reactions nowadays. Rabbit is the most commonly used animal species in intravitreal pharmacokinetics, but it has been criticized as being a poor model of human eye. Search text. The rabbit model permits investigation of chronic aspects of disease because it can act as a control by allowing multiple measurements to be made at different time points. Academia.edu no longer supports Internet Explorer. 141 THE RABBIT AS A MODEL AND FARM ANIMAL AT THE RESEARCH INSTITUTE FOR ANIMAL PRODUCTION NITRA: A REvIEw J. RAFAY1,2*, V. PARKÁNYI1 1NPPC – Research Institute for Animal Production Nitra, Slovak Republic 2University of ss. Rabbit as an animal model for experimental research . Rabbit as an animal model for experimental research ... experimentation is carried out in consultation with the veterinary wing but it is essential that be familiar with experimental protocols of animal model ... have gained favour for their numerous advantages even though they should be ideally used prior to testing in a larger animal model. Rabbit as an animal model for experimental research. 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